CASE REPORT: IMMUNE MEDIATED NECROTIZING MYOPATHY WITH IGG ANTIBODIES TO 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMGCR) MAY PRESENT WITH ACUTE SYSTOLIC HEART FAILURE

Involvement of cardiac muscle is felt to be very uncommon in anti-HMGCR myopathy, and therefore early cardiac evaluation is not considered a high priority for this condition.We herein present the case of a 72 year-old woman admitted due to dyspnea and orthopnea, who, in retrospect, suffered from proximal more than distal muscle weakness for 3 month

As a contribution to the history of the institutional development of the Russian Orthodox Church in the Central Asian parts of the Russian Empire, the present article analyzes the emergence of missionary structures in the Orenburg diocese.The research is based on a wide range of administrative documents of the Orenburg diocese (preserved in the Sta

Background Prognostic models help aid medical decision-making.Various prognostic models are available via websites such as MDCalc, but these models typically predict one outcome, for example, stroke risk.Each model requires individual predictors, for example, age, lab results and comorbidities.There is no clinical tool available to predict multiple

Successful prediction of the likely paths of tumor progression is valuable for diagnostic, prognostic, and treatment purposes.Cancer progression models (CPMs) use cross-sectional samples to identify restrictions in the order of accumulation of driver mutations and thus CPMs encode the paths of tumor progression.Here we analyze the performance of fo

Buildings consume a significant 40% of global energy, where, reducing the building energy consumption to a minimum, virtually zero, has become a thriving research area.Accordingly, this research aimed to determine and portray the huge potential of energy conservation in existing structures by making a retrofit at relatively low costs in finance str